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Targeted Apheresis Cartridge for Preeclampsia (TAC-PE)
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Apheresis is a common and safe procedure used therapeutically to

treat several chronic diseases, even during pregnancy.

Apheresis is a process similar to kidney dialysis in which whole blood is removed from a patient, filtered for a particular substance, and then returned to the patient. Our patent pending technology selectively targets the removal of blood components associated with the symptoms of preeclampsia. Specifically, the TAC-PE removes the harmful sFlt-1 receptors, thereby freeing circulating growth factors to bind to their target receptors in the mother. The TAC-PE is an affinity column that can be integrated into existing therapeutic apheresis devices. It consists of a rigid cylinder filled with immobilized agarose beads conjugated to proprietary sFlt-1 antibodies. To treat the patient, the woman's blood is pumped through an apheresis machine (1), which separates her blood into plasma and blood cells (2). The plasma is then circulated through the TAC-PE device (3), where the harmful sFlt-1 proteins are captured. The cleaned plasma is then remixed with the blood cells (4) and returned to the patient (5).

Targeted Therapy for Preeclampsia

This circuit diagram illustrates the flow of blood from the patient, through the apheresis machine and TAC-PE, and back to the patient.
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